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. Author manuscript; available in PMC: 2018 Apr 13.
Published in final edited form as: J Am Chem Soc. 2017 Apr 10;139(15):5588–5595. doi: 10.1021/jacs.7b01791

Figure 2.

Figure 2

Novel classes of nucleophile probes to profile cysteine oxidation (a) Structural classes of cyclic C-nucleophiles (1–8). In each structure, the nucleophilic carbon is highlighted in the red circle. Rate constants from ref 42. (b) From the pool of cyclic C-nucleophiles, DYn-2 and four new C-nucleophiles were selected on the basis of a range of reaction rate constants and scaffold diversity. (c) Energy-minimized 3-dimensional representation of the probes.