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. Author manuscript; available in PMC: 2018 Apr 13.
Published in final edited form as: J Am Chem Soc. 2017 Apr 10;139(15):5588–5595. doi: 10.1021/jacs.7b01791

Figure 4.

Figure 4

Chemoproteomic analysis of RKO cellular S-sulfenylome. (a) Crystal structures of GAPDH (PDB: 4WNC) showing Cys152, Cys156, and Cys247 labeled by different probes. (b) CARM1 (PDB: 5U4X) showing Cys421 that is labeled by TD. (c) Comparative sequence analysis of peptides labeled with different probes. (d) Heat map of Z-score normalized peak intensities of S-sulfenylated sites labeled with various probes. Values in each row direction have been mean centered and scaled.