. Author manuscript; available in PMC: 2018 Apr 13.

Published in final edited form as: J Am Chem Soc. 2017 Apr 10;139(15):5588–5595. doi: 10.1021/jacs.7b01791

Table 2.

Surface Distribution Analysis of Probe-Labeled Proteins^a

Probe	E (%)	B (%)
DYn-2	35.3	52.9
TD	0.0	80.0
PYD	21.4	71.4
PRD	33.3	55.6
BTD	25.0	62.5
UM	19.6	58.7

Calculations were based on 20 proteins with 3D structure files found in the Protein Data Bank (PDB) that contained both buried and exposed cysteine residues. Abbreviations: E, exposed (RSA > 25%); B, buried (RSA < 10%); UM, unmodified cysteine residues.