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Differential Binding Modes of FG-Nup•NTR Interactions
Disordered FG-Nup214 undergoes a coupled reconfiguration binding with the NTR CRM1⋅RanGTP complex, in contrast to the previously reported archetypal-fuzzy binding mechanism of FG-Nup153⋅Importinβ, indicating that variations in the type and extent of individual FG⋅NTR interactions can drastically change the mechanism of binding between the FG-Nup and its NTR.
