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. Author manuscript; available in PMC: 2018 Apr 13.
Published in final edited form as: Vaccine. 2014 Apr 14;32(26):3122–3127. doi: 10.1016/j.vaccine.2014.04.021

Table 1.

Summary of data on adverse obstetric events following influenza vaccination during pregnancy.

Study Design Study group Control group Vaccine(s) studied Adverse obstetric outcome(s)
Munoz et al. [31] Retrospective matched cohort 225 vaccinated pregnant women 826 unvaccinated pregnant women Trivalent inactivated influenza No significant difference in rates of gestational diabetes or preeclampsia
Tavares et al. [32] Prospective cohort 267 vaccinated pregnant women None AS03-adjuvanted A/H1N1 (2009) Four women (1.5%) diagnosed with preeclampsia/hypertension within 181 days of vaccination; lower than expected rate
Heikkinen et al. [33] Prospective matched cohort 2295 vaccinated pregnant women 2213 unvaccinated pregnant women MF59-adjuvanted A/H1N1 (2009) No difference in rates of preeclampsia (3.5% vaccinated, 3.4% unvaccinated; aOR 1.12, NS). Significantly lower rate of gestational diabetes among vaccinated (1.1% vs 2.2%; aOR 0.48)
Oppermann et al. [34] Prospective matched cohort 323 vaccinated pregnant women 1329 unvaccinated pregnant women AS03-adjuvanted A/H1N1 (2009), A/H1N1 (2009) No difference in rates of preeclampsia (3.2% vaccinated, 4.5% unvaccinated; aOR 1.15, NS)
Conlin et al. [35] Retrospective matched cohort 10,376 A/H1N1 (2009)-exposed pregnant women 7560 pregnant women vaccinated with seasonal influenza vaccine A/H1N1 (2009) No difference in rates of preeclampsia or eclampsia between vaccination groups (5.8% A/H1N1 vs. 5.2% seasonal)
Kallan et al. [36] Retrospective matched cohort 18,612 vaccinated pregnant women 136,914 and 83,298 unvaccinated pregnant women AS03-adjuvanted A/H1N1 (2009) No significant difference in rates of gestational diabetes or preeclampsia delivery diagnoses
Kharbanda et al. [37] Retrospective matched cohort 74,292 vaccinated pregnant women 144,597 unvaccinated pregnant women Trivalent inactivated influenza No difference in rates of gestational hypertension or preeclampsia/eclampsia; significantly lower risk of gestational diabetes among vaccinated, non-significant higher risk of chorioamnionitis among vaccinated
Rubinstein et al. [38] Retrospective matched cohort 7293 vaccinated pregnant women 23,195 unvaccinated pregnant women MF59-adjuvanted A/H1N1 (2009) No significant difference in rates of pregnancy induced hypertension, preeclampsia, or eclampsia