Table 4. Top 20 Activated and Inhibited IPA® Upstream Regulators in ATR and TBT Treated Samples.
| Toxicant: ATR | Toxicant: TBT | ||||||
|---|---|---|---|---|---|---|---|
| Upstream Regulator | Predicted Activation State and z-score 1 | # DE Genes 2 | Upstream Regulator | Predicted Activation State and z-score 1 | # DE Genes 2 | ||
| IFNG | Inhibited | -8.278 | 197 | IFNG | Inhibited | -7.802 | 249 |
| lipopolysaccharide | Inhibited | -7.115 | 248 | lipopolysaccharide | Inhibited | -6.957 | 305 |
| IRF7 | Inhibited | -7.095 | 57 | ↓IRF7 | Inhibited | -6.851 | 62 |
| IFNA2 | Inhibited | -6.932 | 65 | IFNA2 | Inhibited | -6.676 | 78 |
| Interferon α | Inhibited | -6.793 | 79 | Interferon α | Inhibited | -6.605 | 86 |
| poly rI:rC-RNA | Inhibited | -6.782 | 87 | poly rI:rC-RNA | Inhibited | -6.308 | 104 |
| TNF | Inhibited | -6.624 | 255 | ↓IFNL1 | Inhibited | -6.241 | 40 |
| ↓IFNL1 | Inhibited | -6.114 | 38 | IFN Beta | Inhibited | -5.779 | 44 |
| ↓IL1B | Inhibited | -5.961 | 123 | IFNB1 | Inhibited | -5.591 | 72 |
| IFNB1 | Inhibited | -5.785 | 55 | ↓TNF | Inhibited | -5.468 | 323 |
| ↓STAT1 | Inhibited | -5.330 | 71 | Ifnar | Inhibited | -5.393 | 35 |
| IFN Beta | Inhibited | -5.330 | 37 | NKX2-3 | Activated | 5.314 | 82 |
| NKX2-3 | Activated | 5.197 | 69 | IRF3 | Inhibited | -5.269 | 55 |
| ↓IL1RN | Activated | 5.155 | 42 | IRF1 | Inhibited | -4.985 | 51 |
| IRF1 | Inhibited | -5.083 | 44 | EIF2AK2 | Inhibited | -4.933 | 33 |
| TLR9 | Inhibited | -5.019 | 38 | TLR7 | Inhibited | -4.928 | 29 |
| ↑TRIM24 | Activated | 5.000 | 37 | ↓STAT1 | Inhibited | -4.917 | 94 |
| IRF3 | Inhibited | -4.936 | 53 | TLR9 | Inhibited | -4.885 | 44 |
| MAPK1 | Activated | 4.845 | 91 | TRIM24 | Activated | 4.864 | 43 |
| Ifnar | Inhibited | -4.746 | 30 | CHUK | Inhibited | -4.839 | 53 |
1
Activation state is predicted Activated if z-score > 1.96 and Inhibited for z-score < -1.96.
2
Number of genes affected by toxicant treatment that are involved in functions/disease.