Table 6. Top shared Upstream Regulators related to DEGs for five EDC treatments ranked by sum of z-score (from Table S25).
| z-score2 | |||||||
|---|---|---|---|---|---|---|---|
| Regulator1 | ATR | BPA | DEHP | PFOA | TBT | SUM | Num. p≤.05 |
| IFNG | -8.28 | -2.02 | -3.32 | -2.58 | -7.80 | -24.00 | 5 |
| poly rI:rC-RNA | -6.78 | -1.14 | -3.15 | -1.23 | -6.31 | -18.60 | 5 |
| TNF (T) | -6.62 | -4.10 | -1.81 | -5.47 | -18.00 | 4 | |
| lipopolysaccharide | -7.12 | -2.35 | -1.18 | -6.96 | -17.60 | 4 | |
| Interferon alpha | -6.79 | -1.00 | -2.20 | -6.60 | -16.60 | 4 | |
| IFNL1 (A,T) | -6.11 | -2.00 | -6.24 | -14.35 | 4 | ||
| NKX2-3 | 5.20 | 1.89 | 1.91 | 5.31 | 14.31 | 5 | |
| IRF7 (T) | -7.09 | -6.85 | -13.95 | 2 | |||
| IL1B (A) | -5.96 | -2.29 | -1.00 | -4.39 | -13.65 | 4 | |
| IFNA2 | -6.93 | -6.68 | -13.61 | 4 | |||
| MAPK1 | 4.84 | 2.24 | -0.46 | 1.92 | 4.57 | 13.12 | 5 |
| tributyrin | -4.21 | -1.95 | -2.78 | -1.95 | -2.15 | -13.03 | 5 |
| STAT1 (A,T) | -5.33 | -1.50 | -0.85 | -4.92 | -12.60 | 4 | |
| PRL | -4.44 | -0.64 | -2.04 | -0.50 | -4.21 | -11.83 | 5 |
| TGFB1 | -2.97 | -1.85 | -3.52 | -1.24 | -2.04 | -11.63 | 4 |
| IFNB1 | -5.78 | -5.59 | -11.38 | 4 | |||
| MYD88 (T) | -4.48 | -3.07 | -3.82 | -11.37 | 4 | ||
| TLR7 | -4.45 | -1.98 | -4.93 | -11.35 | 4 | ||
| mycophenolic acid | -3.71 | -1.96 | -2.25 | -1.22 | -2.21 | -11.35 | 5 |
| OSM | -4.32 | -2.03 | -0.94 | -3.95 | -11.24 | 4 | |
| IFN Beta | -5.33 | -5.78 | -11.11 | 3 | |||
| TLR9 | -5.02 | -1.13 | -4.88 | -11.03 | 4 | ||
| IL1RN (A) | 5.15 | 1.27 | 4.56 | 10.99 | 5 | ||
| EIF2AK2 | -4.07 | -1.98 | -4.93 | -10.98 | 4 | ||
| IKBKB | -3.50 | -2.57 | -0.96 | -3.84 | -10.87 | 4 | |
| IFN | -4.57 | -2.00 | -4.25 | -10.82 | 4 | ||
1
(A) and (T) indicate the UR itself is affected in ATR and TBT treated cultures
2
Activation state is predicted Activated if z-score > 1.96 and Inhibited for z-score < -1.96.