Table 1.
Description of morphological features post infection (PI) with MmuPV1.
| Time | Morphology | Description |
|---|---|---|
| Week 1 | Wounding | • Partial thickness wound (4 mm2) • Some wounds may have accompanying swelling • Some reddening of ears can be seen post UVB irradiation up to 48 h post treatment. • Several wounds start healing 3–4 days PI |
| Weeks 1–3 | Scarring and/or edema | • Scabs are apparent 4–7 days PI • Some scars may be hypertrophic • In some cases swelling may be seen up to 2 weeks PI |
| Weeks 3–5 | Skin healing without papilloma development (In a subset of mice) | • Scars flatten • Normal looking skin is restored |
| Weeks 3–12 | Papilloma onset and growth (In another subset of mice) | • Clusters of white-brown bumpy papillary projections start appearing that are crusty to touch • Papillomas usually continue to grow at least 2–3 weeks post onset |
| Weeks 12–24 | Papilloma growth/regression | • Subset of papillomas continue to persist and grow in size • Subset of papillomas continue to persist but start regressing • Subset of papillomas completely regress between 18 and 24 weeks PI |