Skip to main content
. Author manuscript; available in PMC: 2019 Apr 6.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Mar 12;498(3):633–639. doi: 10.1016/j.bbrc.2018.03.034

Figure 1. High throughput screening identified E6155 as a new small molecular activator of SIRT1 and augmented insulin-stimulated glucose uptake.

Figure 1

(A) The chemical structure of E6155. (B) Dose-dependent curve of E6155 (in log scale) in SIRT1 activators screening model. (C) Western blotting analysis of ac-p53 and total p53 of whole HepG2 cell lysates. Values are presented as mean±SEM, One-way ANOVA (nonparametric, Bonferroni’s multiple comparison test), *p<0.05, **p<0.01, n=4. (D) E6155 improves the glucose uptake in normal liver L02 cells and (E) skeletal muscle L6 cells in a SIRT1 dependent manner. (D–E) Data are expressed as mean ± SEM, 2-tailed, paired t-test, *p < 0.05, **p < 0.01, vs Control group, n=3.