Table 1.
Distribution of VEGF genotypes and alleles frequencies in ADPKD patients and controls.
|
Group 1 vs Group 4
|
Group 2 vs Group 3
|
|||||||
|---|---|---|---|---|---|---|---|---|
|
Genotype/
Allele |
Group 1: ADPKD patients (n=123) | Group 2: ADPKD-Advanced CKD stage (n=69) | Group 3: ADPKD-Early CKD stage (n=54) | Group 4: Controls (n=100) |
χ2
p-value |
OR (95%CI) | χ2 p-value | OR (95%CI) |
| rs699947 (-2578C>A) |
||||||||
| CC | 0.309 | 0.275 | 0.352 | 0.37 | 0.003* | 0.644 | ||
| CA | 0.626 | 0.652 | 0.593 | 0.44 | ||||
| AA | 0.065 | 0.073 | 0.056 | 0.19 | ||||
| C | 0.622 | 0.601 | 0.648 | 0.59 | 0.491 | 0.87 (0.59-1.28) | 0.454 | 1.22 (0.72-2.05) |
| A | 0.378 | 0.399 | 0.352 | 0.41 | ||||
| rs1570360 (-1154G>A) |
||||||||
| GG | 0.431 | 0.42 | 0.444 | 0.57 | 0.093 | 0.862 | ||
| GA | 0.48 | 0.478 | 0.481 | 0.34 | ||||
| AA | 0.089 | 0.101 | 0.074 | 0.09 | ||||
| G | 0.671 | 0.659 | 0.685 | 0.74 | 0.111 | 1.39 (0.92-2.11) | 0.669 | 1.21 (0.65-1.92) |
| A | 0.329 | 0.341 | 0.315 | 0.26 | ||||
*
Statistically significant