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. 2018 Apr 13;5(2):ENEURO.0412-17.2018. doi: 10.1523/ENEURO.0412-17.2018

Figure 2.

Figure 2.

Expression of Trpv1, Grm2, and Grm3 mRNA transcripts in dissociated mouse and human sensory neurons. A, Size distribution of total and Trpv1 + mouse DRG neuron populations; mean diameter of total neurons: 17.7 ± 0.2 μm (n = 395 neurons, n = 4 preps), mean diameter of Trpv1+ neurons: 20.3 ± 0.4 μm (n = 147 neurons). B, Size distribution of total and TRPV1+ human DRG neuron populations; mean diameter of total neurons: 31.9 ± 0.5 μm (n = 258 neurons, n = 5 donors), mean diameter of TRPV1+ neurons: 33.9 ± 0.9 μm (n = 83 neurons). Data are reported as mean ± SEM. C, The mean diameter of total human DRG neurons was significantly larger than that of total mouse DRG neurons (unpaired t test, **** p = 1.0 × 10–14). Data are presented as mean ± SD. Percentage of total mouse (D) and human (E) DRG neurons that expressed Trpv1, Grm2, and Grm3, as well as the percentage of neurons that coexpressed one mRNA transcript with another. Pie charts showing the percentage of Trpv1 + mouse (F) and human (G) DRG neurons that coexpressed Grm2, Grm3, or both transcripts. No significant differences in gene transcript expression of total neurons or Trpv1 + neuron subpopulations were observed between species.