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. 2018 Apr 13;13(4):e0195981. doi: 10.1371/journal.pone.0195981

Table 2. Definition, justification, interpretation of used biomarkers with zooplankton examples from literature.

AO = antioxidant, OD = oxidative damage, O2- = superoxide radical, H2O2 = hydrogen peroxide.

Biomarker Definition Justification Interpretation
↑ or ↓
Example of species and study area Reference
GSH: GSSG Reduced: oxidised glutathione ratio OD Assays glutathione redox state [29] Low ratio or increase in GGSG indicate stress Limnocalanus macrurus, Baltic Sea, FI [16]
GR Glutathione reductase AO Reduces GSSG back to GSH [30] ↑ indicates more AO L. macrurus, Baltic Sea, FI [16]
GST Glutathione S-transferase AO Catalyzes reactions that detoxify harmful compounds [31] ↑ indicates more AO L. macrurus, Baltic Sea, FI; Eurytemora affinis, Seine estuary, FR [16, 27]
SOD Superoxide dismutase AO Part of enzymatic defense to remove O2- [31] ↑ indicates more AO L. macrurus, Baltic Sea, FI [16]
CAT Catalase AO Part of enzymatic defense to remove H2O2 [31] ↑ indicates more AO Boeckella gibbosa, Mixodiaptomus laciniatus, Lake Los Cantaros, ARG; Lake La Caldera, ESP [32]
ORAC Oxygen reactive absorbance capacity AO Assesses antioxidant capacity [33] ↑ indicates more AO Acartia bifilosa, Baltic Sea, FI [21]
LPX Lipid peroxidation OD Oxidative degradation of lipids in cell membrane, resulting in cell damage [33] ↑ indicates stress L. macrurus, Baltic Sea, FI [16]