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. 2018 Apr 3;14(4):e1006055. doi: 10.1371/journal.pcbi.1006055

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© 2018 Zarai, Tuller

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 1 — (a) Study flow diagram. Red color indicates blocks/functions simulated in this study. Dashed blocks specify measurements. Variables correspond to mRNA levels ( ${\tilde{L}}_{h}$ ) and various measurements ( $z_{a}, \overline{z}, {\overline{R}}_{a}, {\hat{R}}_{a}, {\overline{ρ}}_{a}, {\hat{ρ}}_{a}$ ). See the main text for details. (b) Topology of the computational model used in this study, which includes m mRNAs and a shared free pool of ribosomes. Gⁱ(z) denotes the initiation rate to mRNA i, and Rⁱ(t) denotes the translation rate of mRNA i at time t. (c) An example of the free ribosomal pool (top), the GFP translation rate (middle) and the GFP mean ribosomal density (bottom) as a function of t ∈ [0, 192] for a periodically varying GFP mRNA levels with period T = 16.