Fig 2. The effect of endogenous gene mRNA levels.

(a) z_a, ${\bar{R}}_a$, and ${\bar{\rho }}_a$ as a function of the number of oscillating genes chosen incrementally from a mRNA levels-sorted list of genes (see details in the Materials and methods section), (dashed-line), and genes chosen randomly from the gene list (solid-line), for A = 1/2. Note that the results for z_a and ${\bar{\rho }}_a$ when oscillating a typical gene set are very similar (the solid-line for z_a cannot be distinguished from the solid-line ${\bar{\rho }}_a$) (b) The corresponding variances. (c) z_a, ${\bar{R}}_a$, and ${\bar{\rho }}_a$ as a function of the normalized amplitude A ∈ [0.1, 0.9] when oscillating the cell cycle related genes. (d) The corresponding variances.