Fig 2. Calmodulin C-term domain binding the voltage-gated sodium channel Na_V1.2.

a) Ca²⁺-free state (apo) and b) Ca²⁺-bound state (holo). The structures have PDB accession numbers a) 2KXW and b) 4JPZ. The target protein backbone is shown as a violet ribbon and its side chains are depicted as violet sticks. Hydrophobic residues are visualized in a white mesh. Key hydrophobic residues found in this paper’s analysis are highlighted in different colors. The residues are shown in S1 and S3 Figs.