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. Author manuscript; available in PMC: 2018 May 2.
Published in final edited form as: Nature. 2017 Oct 18;551(7678):115–118. doi: 10.1038/nature24057

Figure 4. Circulating lactate is a primary TCA substrate in tumours.

Figure 4

a–c,Normalized labelling of serum glucose, lactate, and glutamine and of tumour TCA intermediates by infused 13C-glucose, 13C-lactate, and 13C-glutamine in three GEMM tumours in fasted mice. a, KrasLSL-G12D/+ Trp53−/− (KP) lung cancer (n = 3 for glucose and lactate and n = 4 for glutamine infusion). b, KrasG12D/+Stk11−/− lung cancer (n = 3). Stk11 is also known as Lkb1 and the mouse model is called KL lung cancer. c, KrasLSL-G12D/+Trp53−/−Ptf1aCRE/+ (KPf/fC) pancreas cancer (n = 3 for glucose and n = 4 for lactate and glutamine). Data are mean ± s.d. d, Direct circulating nutrient contributions to tumour TCA cycle, data are mean ± s.e.m. e, Schematic representation, glucose feeds the TCA cycle via circulating lactate.