Extended Data Figure 9. Scatter plots of normalized labelling of TCA intermediates in the three types of tumours by ¹³C-glucose versus that by ¹³C-lactate.

a, Kras^LSL-G12D/+Trp53^−/− (KP) non-small cell lung cancer (n = 3 for ¹³C-glucose and ¹³C-lactate infusions, and n = 4 for ¹³C-glutamine infusion). b, Kras^LSL-G12D/+ Stk11^−/− (KL) lung cancer (n = 3 mice for infusion of each tracer). c, Kras^LSL-G12D/+Trp53^−/−Ptf1a^CRE/+ (KP^f/fC) pancreatic ductal adenocarcinoma (n = 4 for ¹³C-glucose infusion, n = 3 for ¹³C-lactate and ¹³C-glutamine infusions). Values are mean ± s.d. Data are from Fig. 4a–c. The solid line represents the expected labelling by ¹³C-glucose assuming that glucose feeds the TCA cycle solely through circulating lactate. The dashed line indicates the expected labelling by ¹³C-lactate, assuming that lactate feeds the TCA cycle solely through circulating glucose.