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. Author manuscript; available in PMC: 2019 Apr 12.
Published in final edited form as: J Med Chem. 2018 Mar 26;61(7):2680–2693. doi: 10.1021/acs.jmedchem.7b01277

Figure 3.

Figure 3

Chemical structure of 34 and overlay of 34(green):DCN1(electrostatic potential surface) and 1(orange):DCN1 X-ray co-crystal structures (PDB 6BG3 and 5V83), highlighting that the acetate substitution, which targeted the N-acetyl pocket flipped into the Leu pocket.