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. 2018 Mar 2;50(3):e452. doi: 10.1038/emm.2017.287

Figure 5.

Figure 5

NKAα1 altered urate transporter expression in cultured human PTECs. NKA α1 expression vector or siRNA was added to cells for 30 h to overexpress or inhibit NKA α1 before 48 h of UA 100 μg ml−1 stimulation. Except OAT3 (m), UA significantly increased the expressions of SLC5A8 (a), SLC5A12 (b), URAT1 (c), OAT10 (d), OAT4 (e), GLUT9 (f), MRP4 (g), ABCG2 (h), NPT1 (i), NPT4 (j), OAT2 (k), OAT1 (l) and SLC13A3 (n). NKA α1 expression vector significantly increased UARAT1 (c) and reduced MRP4 (g) and NPT4 (j) expressions, whereas it had no effect on other urate transporters. NKA α1 siRNA reduced SLC5A8 (a), UARAT1 (c) and OAT4 (e) expressions, wheresa it had no effect on other urate transporters. *P<0.05 vs Cont, **P<0.01 vs Cont, #P<0.05 vs UA, ##P<0.01 vs UA.