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. 2018 Mar 2;50(3):e452. doi: 10.1038/emm.2017.287

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Hyperuricemicrats developed microalbuminuria and slight mesangial expansion. OA gastric administration for 7 weeks showed a tendency of elevated UA levels and significantly increased serum UA level at the 10th week in SD rats (A). Urinary UA were not different among Cont 10w, OA 10w and Feb 10w groups (B). OA started to increase urinary albumin/creatinine ratio (ACR) at the 4th week and maintained this effect till the 10th week (C). Feb treatment showed a tendency of reducing urinary ACR in hyperuricemic rats (D). OA induced a slight increase in glomerular size and mesangial expansion at the 7th week and the changes were more significant at the 10th week (E). Feb treatment reduced serum UA levels and renal mesangial expansion in OA-administered rats.*P<0.05 vs Cont, **P<0.01 vs Cont, ##P<0.01 vs OA 10w.