| ANKRD20A2 |
Ankyrin repeat domain 20 family member A2 |
Unknown |
Florio, Pollen, Miller |
Homo (before Neandertal-Denisovan split) |
Five ankyrin repeats, three coiled coil motifs [UniProt] |
| ANKRD20A4 |
Ankyrin repeat domain 20 family member A4 |
Unknown |
Florio, Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Five ankyrin repeats, three coiled coil motifs [UniProt] |
| ARHGAP11B |
Rho GTPase activating protein 11B |
Basal progenitor amplification (Florio et al., 2015) |
Florio, Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
One nucleotide substitution led to a novel splice donor site in exon five resulting in a novel and unique C-terminal sequence and a loss of Rho-GAP activity (Florio et al., 2015; Florio et al., 2016) |
| CBWD6 |
COBW Domain Containing 6 |
Unknown |
Pollen, Miller |
Homo (before Neandertal-Denisovan split) |
CobW domain, ATP binding sites [UniProt] |
| DHRS4L2 |
Dehydrogenase/reductase 4 like 2 |
Maybe an NADPH dependent retinol oxidoreductase [RefSeq] |
Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Unknown |
| FAM182B |
Family with sequence similarity 182 member B |
Unknown |
Fietz, Miller |
Homo (before Neandertal-Denisovan split) |
Removal of a stop codon resulting in an open reading frame in humans (this publication) |
| FAM72B |
Family with sequence similarity 72 member B |
Unknown |
Florio, Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Unknown |
| FAM72C |
Family with sequence similarity 72 member C |
Unknown |
Florio, Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Unknown |
| FAM72D |
Family with sequence similarity 72 member D |
Unknown |
Florio, Fietz, Miller |
Homo (before Neandertal-Denisovan split) |
Unknown |
| GTF2H2C |
GTF2H2 family member C |
Unknown |
Pollen, Miller |
Homo (before Neandertal-Denisovan split) |
VWFA domain, C4-type zinc finger motif [UniProt] |
| NBPF10 |
Neuroblastoma Breakpoint Family Member 10 |
Contains DUF1220 domains which have been implicated in a number of developmental and neurogenetic diseases (e.g. microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies) [RefSeq] |
Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Tandemly repeated copies of DUF1220 protein domains [RefSeq], coiled coil domain [UniProt] |
| NBPF14 |
Neuroblastoma Breakpoint Family Member 14 |
Contains DUF1220 domains which have been implicated in a number of developmental and neurogenetic diseases (e.g. microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies) [RefSeq] |
Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Tandemly repeated copies of DUF1220 protein domains [RefSeq], coiled coil domain [UniProt] |
| NOTCH2NL |
Notch 2 N-terminal like |
Unknown |
Florio, Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
6 EGF-like domains [UniProt] |
| SMN2 |
Survival of motor neuron 2, centromeric |
Loss of SMN1 and SMN2 results in embryonic death; mutations in SMN1 are associated with spinal muscular atrophy, mutations in SMN2 do not lead to disease; forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein [RefSeq] |
Pollen, Miller |
Homo (after Neandertal-Denisovan split) |
Evolved after the split from Neanderthal and Denisovan (Dennis et al., 2017); telomeric (SMN1) and centromeric (SMN2) copies of this gene are nearly identical and encode the same protein; critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer; the full length protein encoded by this gene localizes to both the cytoplasm and the nucleus [RefSeq]; GEMIN2 binding site, tudor domain, RPP20/POP7 interaction site, SNRPB binding site, SYNCRIP interaction site [UniProt] |
| ZNF492 |
Zinc finger protein 492 |
Unknown |
Florio, Fietz, Pollen |
Homo (before Neandertal-Denisovan split) |
Human ZNF492 is a chimera consisting of the original KRAB repressor domain and the acquired ZNF98 DNA binding domain (this publication); KRAB domain and 13 C2H2 zinc finger motifs [UniProt] |
| ALG1L |
ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase like |
Unknown |
Pollen, Miller |
Hominini |
Unknown |
| CBWD2 |
COBW domain containing 2 |
Unknown |
Pollen, Miller |
Hominini |
CobW domain, ATP binding sites [UniProt] |
| TMEM133 |
Transmembrane protein 133 |
Unknown |
Fietz, Miller, Johnson |
Hominini |
Intronless gene [RefSeq]; transmembrane protein without signal peptide and two predicted transmembrane domains (Protter) |
| HHLA3 |
HERV-H LTR-associating 3 |
Unknown |
Fietz, Pollen |
Homininae |
Unknown |
| TMEM99 |
Transmembrane protein 99 |
Unknown |
Fietz, Miller |
Hominidae |
Transmembrane protein with signal peptide and three transmembrane domains [UniProt, Protter] |
| ZNF90 |
Zinc finger protein 90 |
Unknown |
Florio, Pollen |
Hominidae |
KRAB domain and 15 C2H2 zinc finger motifs [UniProt] |
| CCDC74B |
Coiled-coil domain containing 74B |
Unknown |
Fietz, Pollen, Miller, Johnson |
Hominoidae |
Coiled-coil motif [UniProt] |
| C9orf47 |
Chromosome nine open reading frame 47 |
Unknown |
Fietz, Miller, Johnson |
Hominoidae |
Signal peptide [UniProt, Protter] |
| GLUD2 |
Glutamate Dehydrogenase 2 |
Localized to the mitochondrion, homohexamer, recycles glutamate during neurotransmission and catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate [RefSeq] |
Miller, Johnson |
Hominoidae |
Arose by retroposition (intronless) (this publication) |
| PTTG2 |
Pituitary tumor-transforming 2 |
Unknown |
Fietz, Miller |
Hominoidae |
Arose by retroposition; reading frame remained open only in apes (this publication); destruction box, SH3 binding domain [UniProt] |
| APOL2 |
Apolipoprotein L2 |
Is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles [RefSeq] |
Florio, Fietz, Pollen, Johnson |
Catarrhini |
Signal peptide [UniProt, Protter] |
| APOL4 |
Apolipoprotein L4 |
May play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver [RefSeq] |
Fietz, Miller |
Catarrhini |
Signal peptide [UniProt, Protter] |
| BTN3A2 |
Butyrophilin subfamily three member A2 |
Immunoglobulin superfamily, may be involved in the adaptive immune response [RefSeq] |
Fietz, Pollen, Miller |
Catarrhini |
Signal peptide, Ig-like V-type domain, coiled coil motif, one transmembrane domain [UniProt, Protter] |
| BTN3A3 |
Butyrophilin Subfamily 3 Member A3 |
Major histocompatibility complex (MHC)-associated gene |
Fietz, Miller |
Catarrhini |
Arose by triplication duplication: BTN3A1 is likely the ancestral gene, BTN3A1 duplicated once and this 'copy' duplicated to BTN3A2 and BTN3A3. This triplication happened in the human-rhesus ancestor since marmoset has only a single gene (this publication); type I membrane protein with two extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain [UniProt] |
| MICA |
MHC class I polypeptide-related sequence A |
Is a ligand for the NKG2-D type II integral membrane protein receptor; functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells; variations have been associated with susceptibility to psoriasis one and psoriatic arthritis [RefSeq] |
Florio, Fietz, Miller |
Catarrhini |
Signal peptide, Ig-like C1-type domain, one transmembrane domain [UniProt, Protter] |
| MT1M |
Metallothionein 1M |
Unknown |
Miller, Johnson |
Catarrhini |
Two metal-binding domains [UniProt] |
| SLFN13 |
Schlafen Family Member 13 |
Unknown |
Florio, Johnson |
Catarrhini |
Unknown |
| ZNF100 |
Zinc finger protein 100 |
Unknown |
Fietz, Pollen |
Catarrhini |
KRAB domain and 12 C2H2 zinc finger motifs [UniProt] |
| ZNF222 |
Zinc Finger Protein 222 |
Unknown |
Pollen, Miller |
Catarrhini |
KRAB domain and 10 C2H2 zinc finger motifs [UniProt] |
| ZNF43 |
Zinc finger protein 43 |
Unknown |
Fietz, Pollen |
Catarrhini |
KRAB domain and 22 C2H2 zinc finger motifs [UniProt] |
| ZNF695 |
Zinc finger protein 695 |
Unknown |
Florio, Fietz, Miller |
Catarrhini |
KRAB domain and 13 C2H2 zinc finger motifs [UniProt] |
| ZNF724 |
Zinc finger protein 724 |
Unknown |
Florio, Fietz, Pollen |
Catarrhini |
KRAB domain and 16 C2H2 zinc finger motifs [UniProt] |
| ZNF726 |
Zinc finger protein 726 |
Unknown |
Florio, Fietz |
Catarrhini |
KRAB domain and 20 C2H2 zinc finger motifs [UniProt] |
| ZNF730 |
Zinc finger protein 730 |
Unknown |
Fietz, Johnson |
Catarrhini |
KRAB domain and 12 C2H2 zinc finger motifs [UniProt] |
| ZNF732 |
Zinc finger protein 732 |
Unknown |
Florio, Pollen |
Catarrhini |
KRAB domain and 16 C2H2 zinc finger motifs [UniProt] |
| ZNF816 |
Zinc finger protein 816 |
Unknown |
Florio, Fietz, Pollen, Miller |
Catarrhini |
KRAB domain and 15 C2H2 zinc finger motifs [UniProt] |
| ZNF93 |
Zinc finger protein 93 |
Unknown |
Pollen, Miller |
Catarrhini |
KRAB domain and 17 C2H2 zinc finger motifs [UniProt] |
| HEPN1 |
Hepatocellular carcinoma, down-regulated 1 |
Transient expression of this gene significantly inhibits cell growth and suggests a role in apoptosis; downregulated or lost in hepatocellular carcinomas [RefSeq] |
Florio, Fietz, Miller |
Simiiformes |
Expressed in the liver; encodes a short peptide, predominantly localized to the cytoplasm [RefSeq] |
| KIF4B |
Kinesin family member 4B |
A microtubule-based motor protein that plays vital roles in anaphase spindle dynamics and cytokinesis [RefSeq] |
Fietz, Pollen |
Simiiformes |
Intronless retrocopy of kinesin family member 4A [RefSeq]; kinesin motor domain, ATP binding site, coiled coil, nuclear localization signal, PRC1 interaction domain [UniProt] |
| ZNF20 |
Zinc finger protein 20 |
Unknown |
Fietz, Miller |
Simiiformes |
KRAB domain and 15 C2H2 zinc finger motifs [UniProt] |
| ZNF680 |
Zinc finger protein 680 |
Unknown |
Florio, Pollen |
Simiiformes |
KRAB domain and 12 C2H2 zinc finger motifs [UniProt] |
| ZNF718 |
Zinc finger protein 718 |
Unknown |
Fietz, Pollen |
Simiiformes |
KRAB domain and 11 C2H2 zinc finger motifs [UniProt] |
| ZNF788 |
Zinc finger family member 788 |
Unknown |
Fietz, Pollen |
Simiiformes |
No KRAB domain, 17 C2H2 zinc finger motifs [UniProt] |
| MT1E |
Metallothionein 1E |
Unknown |
Pollen, Miller |
Haplorrhini |
Two metal-binding domains [UniProt] |
| TNFRSF10D |
TNF receptor superfamily member 10d |
Does not induce apoptosis and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. [RefSeq] |
Florio, Fietz |
Haplorrhini |
Signal peptide, TRAIL-binding domain, one transmembrane domain, truncated death domain [UniProt, Protter] |
