TABLE 5.

Age- and season-adjusted incidence ratio (IR) for first myocardial infarction and first stroke stratified by age <65 and ≥65 years in periods after Streptococcus pneumoniae and respiratory viruses (combined) compared with baseline time

Time period after sample days	IR for S. pneumoniae (95% CI)	p-value	IR for respiratory viruses (95% CI)	p-value
Outcome: myocardial infarction aged <65 years#
1–3	7.97 (1.97–32.2)	0.004	16.1 (5.12–50.9)	<0.001
4–7	12.7 (4.69–34.4)	<0.001	4.20 (0.59–30.1)	0.15
8–14	1.77 (0.25–12.7)	0.572	∼0	0.997
15–28	1.93 (0.48–7.81)	0.355	4.08 (1.29–12.9)	0.017
Baseline	1.00		1.00
Outcome: myocardial infarction aged ≥65 years¶
1–3	5.16 (1.65–16.1)	0.005	∼0	0.998
4–7	∼0	0.998	2.35 (0.33–17.0)	0.40
8–14	1.60 (0.40–6.45)	0.51	1.57 (0.22–11.2)	0.65
15–28	2.09 (0.86–5.06)	0.10	0.82 (0.11–5.9)	0.85
Baseline	1.00		1.00
Outcome: stroke aged <65 years+
1–3	37.4 (13.7–102)	<0.001	23.4 (5.71–96.3)	<0.001
4–7	7.83 (1.09–56.4)	0.041	∼0	0.998
8–14	14.2 (4.48–45.2)	<0.001	10.5 (2.55–42.9)	0.001
15–28	9.74 (3.56–26.7)	<0.001	5.90 (1.68–20.7)	0.006
Baseline	1.00		1.00
Outcome: stroke aged ≥65 years§
1–3	5.21 (1.29–21.0)	0.02	∼0	0.999
4–7	7.69 (2.84–20.8)	<0.001	6.83 (1.66–28.1)	0.008
8–14	2.35 (0.58–9.48)	0.23	2.33 (0.32–16.8)	0.40
15–28	2.45 (0.91–6.60)	0.08	2.52 (0.62–10.3)	0.20
Baseline	1.00		1.00

^#: n=498; ^¶: n=729; ⁺: n=301; ^§: n=461.