FIGURE 2.

QUADAS-2 summaries. a and c) Risk of Bias and Applicability Concerns summary about each QUADAS-2 domain presented as percentages across the 94 included datasets for rifampicin (RIF) and isoniazid (INH) resistance compared with phenotypic culture-based reference standard (of note, four datasets only contributed to RIF). The summaries for the datasets for RIF and INH compared with composite reference standard are not displayed separately since these datasets are a subset of the 94 datasets displayed below and thus the figures displayed are thought to be accordingly representative. b and d) Risk of Bias and Applicability Concerns summary about each QUADAS-2 domain presented as percentages across the six included datasets for Mycobacterium tuberculosis detection compared with a culture-based reference standard.