Table 2.

Cumulative incidence of cardiovascular and metabolic conditions in strata by age at hysterectomy with ovarian conservation

Condition	Hysterectomy				Referent Women				Unadjusted Models^b		Adjusted Models^c
Condition	N at Risk	Person -years	N of Events	Absolute Risk^a % (95% CI)	N at Risk	Person -years	N of Events	Absolute Risk^a % (95% CI)	Hazard Ratio (95% CI)	P	Hazard Ratio (95% CI)	P
Age ≤35 years
Hyperlipidemia	518	8,995	211	57.3 (50.9-63.9)	517	8,419	173	57.3 (50.8-63.9)	1.18 (0.97-1.44)	0.11	1.02 (0.82-1.26)	0.88
Hypertension	519	9,736	160	44.7 (38.6-51.3)	521	9,138	129	38.6 (32.5-45.3)	1.21 (0.96-1.53)	0.10	1.13 (0.89-1.44)	0.31
Diabetes	524	10,502	124	38.7 (32.4-45.7)	524	9,757	93	33.0 (26.8-40.1)	1.30 (1.00-1.70)	0.052	1.22 (0.92-1.62)	0.16
Obesity	469	8,519	126	36.6 (30.7-43.3)	502	8,423	106	33.7 (28.0-40.2)	1.18 (0.91-1.52)	0.21	1.07 (0.82-1.41)	0.60
Cardiac arrhythmias	522	10,336	118	35.6 (29.8-42.3)	526	9,835	81	25.5 (20.3-31.9)	1.46 (1.10-1.93)	0.008	1.36 (1.00-1.84)	0.049
Coronary artery disease	529	11,174	40	13.2 (9.3-18.6)	529	10,455	16	7.1 (3.9-12.7)	2.49 (1.40-4.43)	0.002	2.49 (1.39-4.47)	0.002
Congestive heart failure	528	11,353	16	4.9 (2.7-8.7)	529	10,556	3	0.3 (0.0-2.3)	5.24 (1.54-17.82)	0.008	4.59 (1.32-15.94)	0.02
Stroke	527	11,233	21	5.0 (2.8-8.8)	529	10,497	14	4.8 (2.8-8.1)	1.51 (0.76-2.99)	0.23	1.14 (0.50-2.58)	0.75
Age 36 to 50 years
Hyperlipidemia	1,216	18,212	724	78.0 (74.4-81.4)	1,243	18,325	619	73.5 (69.7-77.3)	1.19 (1.08-1.33)	<0.001	1.14 (1.03-1.27)	0.01
Hypertension	1,217	20,199	570	65.5 (61.4-69.5)	1,244	20,294	463	58.3 (54.0-62.7)	1.26 (1.12-1.42)	<0.001	1.21 (1.07-1.36)	0.002
Diabetes	1,262	24,156	421	52.6 (48.4-56.8)	1,277	23,406	363	49.2 (45.1-53.5)	1.13 (0.99-1.30)	0.07	1.08 (0.94-1.24)	0.27
Obesity	1,131	20,225	330	36.5 (33.0-40.3)	1,177	20,636	263	32.4 (28.9-36.2)	1.28 (1.09-1.50)	0.003	1.20 (1.02-1.41)	0.03
Cardiac arrhythmias	1,263	24,636	366	42.9 (39.0-47.0)	1,273	24,127	288	38.1 (34.2-42.2)	1.27 (1.09-1.47)	0.002	1.21 (1.04-1.41)	0.01
Coronary artery disease	1,288	26,582	181	22.7 (19.5-26.4)	1,292	25,664	124	16.3 (13.5-19.5)	1.44 (1.15-1.80)	0.001	1.34 (1.07-1.68)	0.01
Congestive heart failure	1,293	28,066	41	5.6 (3.9-7.9)	1,292	26,445	51	7.2 (5.3-9.7)	0.76 (0.51-1.13)	0.18	0.63 (0.42-0.95)	0.03
Stroke	1,291	27,498	92	10.6 (8.4-13.4)	1,294	26,293	65	9.5 (7.4-12.3)	1.37 (1.00-1.87)	0.048	1.22 (0.88-1.67)	0.23
Age >50 years
Hyperlipidemia	245	2,848	134	81.2 (69.4-90.6)	255	3,048	114	75.9 (64.4-85.9)	1.26 (1.01-1.57)	0.04	1.19 (0.95-1.50)	0.12
Hypertension	207	2,449	141	90.1 (82.9-95.1)	198	2,172	123	84.5 (76.8-90.7)^a	1.00 (0.80-1.25)	0.98	0.94 (0.75-1.18)	0.62
Diabetes	251	4,011	86	58.7 (48.2-69.4)	255	3,835	79	59.4 (48.2-70.9)	1.01 (0.76-1.36)	0.93	1.00 (0.74-1.35)	0.98
Obesity	215	3,517	43	27.6 (20.1-37.0)	229	3,473	37	22.1 (16.0-30.2)	1.18 (0.76-1.83)	0.46	1.17 (0.75-1.83)	0.50
Cardiac arrhythmias	258	3,859	136	75.6 (67.2-83.2)	252	3,734	123	78.6 (69.8-86.3)	1.04 (0.83-1.32)	0.71	1.02 (0.81-1.29)	0.86
Coronary artery disease	255	4,149	101	53.9 (45.2-63.2)	257	4,024	82	44.7 (36.8-53.4)	1.16 (0.87-1.56)	0.31	1.15 (0.85-1.56)	0.35
Congestive heart failure	268	4,698	70	39.2 (31.3-48.2)	263	4,283	76	45.4 (36.6-55.3)	0.79 (0.57-1.09)	0.15	0.84 (0.60-1.17)	0.30
Stroke	269	4,773	58	36.9 (28.9-46.4)	264	4,290	66	41.2 (32.4-51.3)	0.77 (0.54-1.08)	0.13	0.80 (0.56-1.14)	0.22

Absolute cumulative risk at 30 years after hysterectomy (or index) calculated using the Kaplan-Meier method. For hypertension, the Kaplan-Meier estimate at 25 years after index was reported for referent women in the age >50 year stratum because this was the maximum length of follow-up available for these women. The estimates were adjusted using inverse probability weights derived from a logistic regression model including all 20 chronic conditions present at baseline, years of education (≤12, 13-16, >16, unknown), race (white vs nonwhite), and age and calendar year at baseline (continuous). These adjustments were performed separately in each stratum to maximize the balance at baseline.

Hazard ratios calculated using Cox proportional hazards models with age as the time scale.

Hazard ratios calculated using Cox proportional hazards models with age as the time scale and adjusted using inverse probability weights derived from a logistic regression model including all 20 chronic conditions present at baseline, years of education (≤12, 13-16, >16, unknown), race (white vs nonwhite), and age and calendar year at baseline (continuous). These adjustments were performed separately in each stratum to maximize the balance at baseline.