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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Transl Res. 2017 Nov 7;195:48–61. doi: 10.1016/j.trsl.2017.10.012

Fig 3.

Fig 3

TRAF6 as a ubiquitin ligase that mediates the addition of Lys63-linked polyubiquitin chains to substrates. A. Overview of the ubiquitin proteasome system and the functional differences between Lys48-linked polyubiquitin chains targeted substrates for 26S proteasome degradation and the Lys63-linked polyubiquitin chains that do not lead to substrate degradation. B. Overview of a single ubiquitin molecule and the 7 potential lysines that are present that could be linked to form chains, including the Lys48 and Lys63.