Study	Year of Publication	Number of groups	Surgical Intervention	Result of GTR reported for
				PA	Macroaden oma	Microade noma	NF PA	FP A	G H	AC TH	P R L
Bodhinayake et al.4	2014	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Bokhari et al.5	2013	1	ETSS	✔	✔	✔	✔	✔	✔	✔	✔
Campbell et al.6	2010	1	ETSS	✖	✖	✖	✖	✔	✔	✖	✖
Cappabianca et al.7	2002	1	ETSS	✔	✔	✔	✖	✔	✔	✔	✔
Charalampaki et al.8	2009	1	ETSS	✔	✖	✖	✔	✔	✔	✔	✔
Chi et al.9	2013	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Choe et al.10	2008	2	ETSS	✖	✖	✖	✖	✔	✔	✔	✖
			MTSS	✖	✖	✖	✖	✔	✔	✔	✖
Chone et al.11	2014	1	ETSS	✔	✖	✖	✔	✖	✖	✖	✖
Conrad et al.15	2016	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Constantino et al.16	2016	1	ETSS	✔	✔	✖	✖	✖	✖	✖	✖
Cusimano et al.18	2012	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Dallapiazza et al.19	2014	2	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
			MTSS	✖	✖	✖	✔	✖	✖	✖	✖
Dallapiazza et al.20	2015	1	ETSS	✔	✔	✖	✔	✖	✖	✖	✖
Dehdashti et al.23	2008	1	ETSS	✔	✔	✔	✔	✔	✔	✔	✔
De Paiva Neto et al.21	2010	1		✔	✖	✖	✖	✖	✖	✖	✖
De Witte et al.22	2011	1	ETSS	✔	✔	✖	✖	✖	✖	✖	✖
Duz et al.27	2008	2	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
			MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Fathalla et al.30	2015	2	ETSS	✔	✖	✖	✖	✔	✔	✖	✖
			MTSS	✔	✖	✖	✖	✔	✔	✖	✖
Fomekong et al.31	2014	1	MTSS	✔	✔	✖	✖	✖	✖	✖	✖
Frank et al.32	2006	1	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
Gao et al.33	2016	2	ETSS	✔	✔	✔	✖	✖	✖	✖	✖
			MTSS	✔	✔	✔	✖	✖	✖	✖	✖
Gondim et al.35	2011	1	ETSS	✔	✖	✖	✔	✖	✖	✖	✖
Guo-Dong et al.37	2016	2	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
			MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Guvenc et al.38	2016	2	ETSS	✔	✔	✔	✖	✖	✖	✖	✖
			MTSS	✔	✔	✔	✖	✖	✖	✖	✖
Han et al.39	2013	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Hofstetter et al.42	2011	1	ETSS	✖	✔	✔	✖	✔	✔	✔	✔
Jain et al.44	2007	2	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
			MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Jang et al.45	2016	1	ETSS	✔	✖	✖	✔	✖	✔	✔	✔
Jho et al.47	2001	1	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
Juraschka et al.48	2014	1	ETSS	✔	✔	✖	✖	✖	✖	✖	✖
Karppinen et al.50	2015	2	ETSS	✔	✔	✖	✖	✖	✖	✖	✖
			MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Kenan et al.51	2006	1	ETSS	✖	✔	✖	✖	✖	✖	✖	✖
Kuo et al.54	2016	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Kumar et al.53	2012	1	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
Kurosaki et al.55	2000	1	MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Lampropoulos et al.56	2013	1	MTSS	✖	✖	✖	✔	✔	✔	✔	✔
Liu et al.59	2015	1	MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Messerer et al.64	2011	2	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
			MTSS	✖	✖	✖	✔	✖	✖	✖	✖
Mortini et al.67	2005	1	MTSS	✖	✖	✖	✔	✖	✖	✖	✖
Nakao et al.68	2011	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Nie al.69	2015	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Ogawa et al.71	2015	1	MTSS	✔	✖	✖	✖	✖	✖	✖	✖
O’Malley et al.70	2008	2	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
			MTSS	✔	✖	✖	✖	✖	✖	✖	✖
Pinar et al.74	2015	1	ETSS	✔	✔	✔	✖	✖	✖	✖	✖
Qureshi et al.75	2016	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Sheehan et al.78	1999	2	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
			MTSS	✖	✖	✖	✔	✖	✖	✖	✖
Song et al.80	2014	1	ETSS	✔	✖	✖	✖	✔	✖	✖	✖
Thomas et al.82	2014	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Tosaka et al.83	2015	2	ETSS	✔	✔	✖	✖	✖	✖	✖	✖
Wang et al.84	2015	1	ETSS	✔	✔	✔	✖	✖	✖	✖	✖
Wongsirisuwan et al.86	2014	2	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Yan et al.87	2015	1	MTSS	✔	✖	✖	✖	✔	✖	✖	✔
Yildirim et al.88	2016	1	ETSS	✔	✔	✖	✔	✖	✖	✖	✖
Zaidi et al.89	2016	2	ETSS	✖	✖	✖	✔	✖	✖	✖	✖
			MTSS	✖	✖	✖	✔	✖	✖	✖	✖
Zhan et al.90	2015	1	ETSS	✔	✖	✖	✔	✖	✖	✖	✖
Zhang X et al.91	2008	1	ETSS	✔	✖	✖	✖	✖	✖	✖	✖
Zhou et al.92	2014	1	ETSS	✔	✖	✖	✖	✔	✔	✖	✖

ETSS, Endoscopic Transsphenoidal surgery; MTSS, Microscopic Transsphenoidal Surgery; PA, Pituitary Adenomas; GTR, Gross Tumor Resection; NA, No Available; FPA, Functional Pituitary Adenoma; NFPA, Non- Functional Pituitary Adenoma ACTH, Cushing Disease; PRL, Prolactinoma; GH, Growth Hormone Hypersecretion