Table 2.
Adjusted Association of Peak Acute Kidney Injury Stage and Clinical Frailty Scale Scores at 3- and 12-months
| Variable | 3-month CFS Model | 12-month CFS model |
|---|---|---|
| OR (95% CI) | OR (95% CI) | |
| AKI stage 1 | 1.92 (1.14, 3.24) | 1.87 (1.11, 3.14) |
| AKI stage 2 | 2.40 (1.31, 4.42) | 1.81 (0.94, 3.48) |
| AKI stage 3 | 4.41 (2.20, 8.82) | 2.76 (1.34, 5.66) |
| Baseline creatinine* | 0.83 (0.52, 1.34) | 1.07 (0.63, 1.80) |
| Age* | -- | -- |
| Female | 0.89 (0.59, 1.32) | 1.07 (0.72, 1.61) |
| Black | 1.34 (0.68, 2.65) | 0.98 (0.45, 2.12) |
| Charlson Score† | 1.12 (0.99, 1.26) | 1.11 (0.98, 1.26) |
| SOFA Score† | 0.90 (0.82, 1.00) | 0.89 (0.80, 1.00) |
| APACHE | 0.99 (0.96, 1.02) | 1.01 (0.98, 1.03) |
| Baseline CFS=2 | 2.95 (0.66, 13.23) | 1.55 (0.53, 4.54) |
| Baseline CFS=3 | 4.11 (0.90, 18.84) | 1.84 (0.62, 5.46) |
| Baseline CFS=4 | 6.70 (1.32, 34.10) | 3.06 (0.94, 10.00) |
| Baseline CFS=5 | 7.56 (1.43, 40.01) | 4.75 (1.49, 15.17) |
| Baseline CFS=6 | 19.17 (3.67, 100.24) | 4.67 (1.41, 15.48) |
| Baseline CFS=7 | 22.48 (2.39, 211.11) | 8.89 (0.71, 111.17) |
*
Baseline creatinine was centered. Age was modeled nonlinearly using restricted cubic splines with 3 knots; individual ORs are not generalizable.
†
The Charlson Comorbidity Index and SOFA score were modified to remove the chronic kidney disease and acute kidney injury terms, respectively.
CFS Clinical Frailty Scale, AKI acute kidney injury, SOFA Sequential Organ Failure Assessment, APACHE Acute Physiology and Chronic Health Evaluation