Appendix Table 2.
Details on genotyping study used to estimate HPV prevalence for the cancers and related studies from Massachusetts
| Paper (Year) | Study Type and Number of Cases | Geographic Area | Years Incident Cases Collected | Prevalence HPV + Cases | Findings/Use/Limitations | |
|---|---|---|---|---|---|---|
| Cervical | Oropharyngeal | |||||
| Genotyping Data Nationally | ||||||
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| ||||||
| Sarayia et al (2015) [1] | Cross-sectional study of select US cancer registries, 777 cervical cases, 588 oropharyngeal cases | Los Angeles, Hawaii, Iowa, Kentucky, Florida, Louisiana, Michigan | 1993–2005 1 registry 1993–1999 1 registry 2000–2004 1 registry 1994–2004 4 registries 2004–2005 |
90.6% | 70.1% | Used for HPV + prevalence in our estimates |
|
| ||||||
| Steinau et al (2014) [appendix source 2] | Cross-sectional study of select US cancer registries, 557 oropharyngeal cases | Los Angeles, Hawaii, Iowa, Kentucky, Florida, Louisiana, Michigan | 1995–2005 1 registry 1995–1999 1 registry 2000–2004 1 registry 1994–2004 4 registries 2004–2005 |
NA | 72.4% | High-risk HPV prevalence by registry: Los Angeles = 17 cases (85.0%) Hawaii = 33 cases (84.6%) Iowa = 4 cases (30.7%) Kentucky = 74 cases (63.8%) Florida = 101 cases (72.1%) Louisiana = 75 cases (78.9%) Michigan = 92 cases (68.6%) |
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| Genotyping Data in Massachusetts | ||||||
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| Wright et al (2013) [appendix source 3] | Chart review, Brigham and Women’s Hospital, 80 cervical cases | Boston for treatment | 2005–2011 | 96.3% | NA | To compare MA prevalence to national prevalence |
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| Addison et al (2017) [19] | Case series from Massachusetts General Hospital, 235 oropharynx cases | Boston for treatment | 2002–2012 | NA | 64.7% | To compare MA prevalence to national prevalence Eligible patients had to be undergoing radiation |
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| Lorch et al (2015) [20] | Chart review, Dana Farber Cancer Institute, 500 oropharyngeal cases | Boston for treatment | 2001–2011 | NA | 43% HPV + 44% unknown status | To compare MA prevalence to national prevalence Eligible patients had to be stage III or IV |
| Paper (Year) | Study Type and Number of Cases | Geographic Area | Years Incident Cases Collected | Prevalence HPV + Cases | Findings/Use/Limitations | |
|---|---|---|---|---|---|---|
| Cervical | Oropharyngeal | |||||
| Genotyping Data in Massachusetts | ||||||
|
| ||||||
| Nelson et al (2017) [21] | Population-based greater Boston area, 486 pharyngeal cases | Greater Boston area | 1999–2003 and 2006–2011 | NA | 60.7% | To compare MA prevalence to national prevalence |
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| Nichols et al (2010) [22] | Case series from Partners Healthcare System, 68 oropharynx cases | Massachusetts | 1996–2006 | NA | 78% HPV 16 | To compare MA prevalence to national prevalence Eligible patients had to be undergoing chemoradiation |
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| Ringstrom et al (2002) [23] | Case series from Dana-Farber, 29 oropharynx cases | Boston for treatment | 1994–1998 | NA | 52% HPV 16 oropharynx 64% HPV 16 tonsil |
To compare MA prevalence to national prevalence |
Saraiya M, Unger ER, Thompson TD, et al (2015) US Assessment of HPV Types in Cancers: Implications for Current and 9-Valent HPV Vaccines. JNCI Journal of the National Cancer Institute 107(6):djv086. doi:10.1093/jnci/djv086.
Steinau M, Saraiya M, Goodman MT, et al (2014). Human Papillomavirus Prevalence in Oropharyngeal Cancer before Vaccine Introduction, United States. Emerging Infectious Diseases. 20(5):822–828.
Wright AA, Howitt BE, Myers AP, et al (2013). Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer. 119(21):3776–83.
Addison D, Seidelmann SB, Jangua SA, et al (2017). Human Papillomavirus Status and the Risk of Cerebrovascular Events Following Radiation Therapy for Head and Neck Cancer. J Am Heart Assoc. 6(9):e006453.
Lorch JH, Hanna GJ, Posner MR, et al (2015). Human Papillomavirus and Induction Chemotherapy versus Concurrent Chemoradiotherapy in Locally Advanced Oropahyrygneal Cancer: The Dana Farber Experience. Head & Neck. 38(S1):E1618–E1624.
Nelson HH, Pawlita M, Michaud DS, et al (2017). Immune Response to HPV16 E6 and E7 Proteins and Patient Outcomes in Head and Neck Cancer. JAMA Oncology. 3(2):178–185.
Nichols AC, Finkelstein DM, Faquin WC, et al (2010). Bcl2 and Human Papilloma Virus 16 as Predictors of Outcome following Concurrent Chemoradiation for Advanced Oropharyngeal Cancer. Clin Can Res. 16(7):2138–2146.
Ringstrom E, Peters E, Hasegawa M, et al (2002). Human Papillomavirus Type 16 and Squamous Cell Carcinoma of the head and Neck. Clin Cancer Res. 8(10):3187–3192.