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. 2018 Apr 13;8:5970. doi: 10.1038/s41598-018-24476-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vascular alterations of the superficial plexus in adult Ndph^y/− mice. Lectin-FITC-stained retinal whole mount preparations of 2 months old control (A) and age matched Norrin deficient mice (B) detected reduced outgrowth of the retinal primary plexus. (C,D) Analysis of the retinal vasculature and capillary network by PAS stained retinal digest preparations revealed severe vascular alterations in the retina of 2 months old Ndph^y/− mice (D) compared to age matched control (C). (E,F) Long-term monitoring by in vivo SLO imaging (ICG angiography) between 2 months (E) and 5 months of age (F) did not reveal further overall vascular alterations. SLO images of the same individual are shown.