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. 2018 Apr 13;8:5970. doi: 10.1038/s41598-018-24476-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Detection of neovascularization. At 3 months of age in two out of five eyes NV could be observed. (A,D) SLO angiography with FL, the position of the respective OCT scans (B–F) are depicted. V: ventral, d: dorsal, t: temporal, n: nasal, hs: horizontal scan, vs; vertical scan. In (B) OCT scan (left) with the corresponding retinal cryosection stained with hematoxylin (right) is shown. The histomorphology at 18 months of age corroborated the results obtained by OCT imaging. NV could be detected infiltrating the sub-RPE space and the ONL. The photoreceptor inner segments attached to the ONL appear to be dragged upwards by the invading vessel (yellow arrow), also RPE migration along the invading vessel was observed (red arrows). The detachment of the photoreceptor layer from the RPE was most likely produced by the histological procedure. GCL: ganglion cell layer, IPL: inner plexiform layer, INL: inner nuclear layer, OPL: outer plexiform layer, ONL: outer nuclear layer, OLM: outer limiting membrane, I/OS: photoreceptor inner/outer segment border, RPE: retinal pigment epithelium, CH: choroid. Scale bar, 50 µm.