Fig. 5.

Increased activation of APCs in the dLN 24 and 48 h after vaccination with Matrix-M-adjuvanted influenza HA vaccines. a–b The number of CD69⁺ or CD86⁺ DCs, monocytes, and B lymphocytes recruited to the dLN was measured by flow cytometry 4, 24, and 48 h after i.m. injection of the respective vaccine. c The mean fluorescence intensity (MFI) of MHC class II of on DCs, monocytes, and B lymphocytes in the dLN was measured by flow cytometry 4, 24, and 48 h post-injection. Data are shown as mean of 10 mice per group. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001. MM = Matrix-M adjuvant