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. 2018 Apr 13;8:5984. doi: 10.1038/s41598-018-24295-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Caries lesions in rats challenged with the wild type S. mutans or alr-mutant strain. (A) Stereo microscopy images of caries lesions. (B) Statistical analysis of the Keyes scores. The asterisks indicate significant differences compared to the parental S. mutans strain group. The error bars represent the standard deviation (SD). *P < 0.05. (C) The scores for the enamel lesions (E) represent the incidence of caries. The scores for the slightly dentinal lesions (Ds), moderate dentinal lesions (Dm), and extensive dentinal lesions (Dx) represent the severity of the caries.

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