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. 2018 Apr 13;8:5958. doi: 10.1038/s41598-018-24220-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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4 weeks of LDSTZ-induced diabetic model in male Hhip^+/+ and Hhip^+/− mice from the age of 12 to 16 weeks. (a) Glycemia measurement. (b) Ratio of KW/TL. (c) GFR measurement. (d) Urinary ACR measurement. (e) Renal morphology. PAS staining (scale bar, 50 µm) with semi-quantification of glomerulosclerosis injury score. Grade 0, normal glomeruli; Grade 1, presence of mesangial expansion/thickening of the basement membrane; Grade 2, mild/moderate segmental hyalinosis/sclerosis involving less than 50% total glomerular area; Masson staining (scale bar, 50 µm) with semi-quantification of glomerular fibrosis; p57/Hhip co-IF staining with semi-quantification of p57 positive stained cells per glomerulus. Nox4-IHC staining with semi-quantification of Nox4 positive stained cells per glomerulus. (f) SBP (mmHg) measurement. NS, non-significant vs. Hhip^+/+-Con; Values represent the mean ± SEM.