. 2018 Apr 13;92(9):e01760-17. doi: 10.1128/JVI.01760-17

TABLE 1.

Mixed-model regression analysis of longitudinal trajectories of multiple lymphocyte populations reveals IFN-α blockade-induced changes

Cell population	Treatment (mg/kg AGS-009 by day postinfection)	Slope relative to control	P value	Significance^a
% Ki67⁺PD-1⁺ CD4⁺ T cells	10	−0.002971	0.638
% Ki67⁺PD-1⁺ CD4⁺ T cells	100	−0.015282	0.0204	*
% Ki67⁺ CD4⁺ T_EM cells	10	0.026	0.2298
% Ki67⁺ CD4⁺ T_EM cells	100	−0.06343	0.005	**
% Ki67⁺PD-1⁺ CD4⁺ T_EM cells	10	0.02494	0.1446
% Ki67⁺PD-1⁺ CD4⁺ T_EM cells	100	−0.041388	0.0201	*
% Ki67⁺PD-1⁺ CD8⁺ T cells	10	0.004006	0.6932
% Ki67⁺PD-1⁺ CD8⁺ T cells	100	−0.027423	0.0097	**
% PD-1⁺ CD8⁺ T_CM cells	10	−0.026061	<0.0001	********
% PD-1⁺ CD8⁺ T_CM cells	100	−0.034942	<0.0001	********
% PD-1⁺ CD8⁺ T_TM cells	10	−0.02862	0.0046	**
% PD-1⁺ CD8⁺ T_TM cells	100	−0.04376	<0.0001	********
% Ki67⁺PD-1⁺ CD8⁺ T_TM cells	10	0.001089	0.9005
% Ki67⁺PD-1⁺ CD8⁺ T_TM cells	100	−0.020232	0.0256	*
% Ki67⁺PD-1⁺ CD8⁺ T_EM cells	10	0.016039	0.2045
% Ki67⁺PD-1⁺ CD8⁺ T_EM cells	100	−0.029861	0.0232	*
No. of NK cells per cubic milliliter blood	10	−0.33248	0.1589
No. of NK cells per cubic milliliter blood	100	0.8025	0.0012	**
No. of B cells per cubic milliliter blood	10	−1.0963	0.2307
No. of B cells per cubic milliliter blood	100	−2.3118	0.0155	*
% Ki67⁺ B cells	10	−0.020671	0.0217	*
% Ki67⁺ B cells	100	−0.022517	0.0162	*

*, P < 0.05; **, P < 0.005; ****, P < 0.0001.