Table 1.
Sham | Denervated | |||
---|---|---|---|---|
Control | Leptin | Control | Leptin | |
Short-term study | ||||
Skeletal muscles, g | ||||
Gastrocnemius | 1.63 ± 0.25 | 1.84 ± 0.04 | 1.90 ± 0.07 | 1.71 ± 0.02 |
Plantaris | 0.33 ± 0.05 | 0.36 ± 0.01‡ | 0.38 ± 0.02 | 0.34 ± 0.01‡ |
Soleus | 0.15 ± 0.02 | 0.16 ± 0.00 | 0.17 ± 0.01 | 0.15 ± 0.00 |
TA | 0.61 ± 0.09 | 0.69 ± 0.01 | 0.73 ± 0.03 | 0.66 ± 0.01 |
EDL | 0.15 ± 0.02 | 0.16 ± 0.00 | 0.17 ± 0.01 | 0.15 ± 0.01 |
Adipose tissues, g | ||||
Mesenteric | 2.16 ± 0.44 | 0.48 ± 0.05‡‡‡ | 2.78 ± 0.13 | 0.28 ± 0.11‡‡‡ |
Perirenal | 1.27 ± 0.23 | 0.54 ± 0.11‡‡‡ | 1.64 ± 0.14 | 0.27 ± 0.03‡‡‡ |
Epididymal | 4.36 ± 0.83 | 2.56 ± 0.35‡‡‡ | 5.55 ± 0.17 | 1.27 ± 0.43‡‡‡ |
Retroperitoneal | 2.63 ± 0.56 | 0.54 ± 0.13‡‡‡ | 2.89 ± 0.15 | 0.14 ± 0.09‡‡‡ |
iBAT | 0.33 ± 0.05 | 0.22 ± 0.02‡‡‡ | 0.28 ± 0.03*** | 0.14 ± 0.02‡‡‡*** |
Long-term study | ||||
Skeletal muscles, g | ||||
Gastrocnemius | 1.75 ± 0.07 | 1.74 ± 0.08 | 1.33 ± 0.06*** | 1.24 ± 0.10*** |
Plantaris | 0.35 ± 0.01 | 0.35 ± 0.02 | 0.27 ± 0.01*** | 0.25 ± 0.02*** |
Soleus | 0.15 ± 0.01 | 0.15 ± 0.01 | 0.12 ± 0.01*** | 0.11 ± 0.01*** |
Adipose tissues, g | ||||
Mesenteric | 3.24 ± 0.18 | 0.00 ± 0.00‡‡‡ | 2.8 ± 0.34 | 0.00 ± 0.00‡‡‡ |
Perirenal | 0.94 ± 0.05 | 0.00 ± 0.00‡‡‡ | 0.80 ± 0.13 | 0.00 ± 0.00‡‡‡ |
Epididymal | 4.24 ± 0.25 | 0.00 ± 0.00‡‡‡ | 3.81 ± 0.33 | 0.00 ± 0.00‡‡‡ |
Retroperitoneal | 3.50 ± 0.21 | 0.00 ± 0.00‡‡‡ | 3.28 ± 0.44 | 0.00 ± 0.00‡‡‡ |
iBAT | 0.37 ± 0.02 | 0.22 ± 0.01‡‡‡ | 0.28 ± 0.03*** | 0.12 ± 0.02‡‡‡*** |
TA, tibialis anterior; EDL, extensor digitorum longus; iBAT, interscapular brown adipose tissue.
P < 0.001, Denervated vs. Sham.
P < 0.05;
P < 0.001 Leptin vs. green fluorescent protein (GFP; Control).