Table 1.
Novel goblet cell secretory factors
| Mediator | Goblet Cell Secreted | Secreted by Other Cell Types | Functions | Reference |
|---|---|---|---|---|
| Muc2 | Yes | No | Creates intestinal mucus barrier | (4, 7, 61, 92, 97) |
| Muc3 | Yes | Yes (enterocytes) | Membrane-bound mucin, creates glycocalyx | (61) |
| Muc5Ac | Yes | Yes (enterocytes) | Creates gastric mucus barrier | (53, 93, 96) |
| Relm-β | Yes | No | Varied immune/antimicrobial functions | (15, 16, 29, 92) |
| RegIIIβ | Yes | Yes (enterocytes, immune cells) | Antimicrobial functions | (29, 81) |
| RegIIIγ | Yes | Yes (enterocytes, immune cells) | Antimicrobial functions | (29, 81) |
| Tff3 | Yes | No | Promotes mucosal repair | (37, 73, 95, 127) |
| IgA | No | Yes (B cells) | Antimicrobial and immunomodulatory functions | (98) |
| pIgR | ? | Yes | Transports antibodies across the intestinal epithelium into mucus | (98) |
| Fcgbp | Yes | No | Crosslinks Muc2 | (62, 96) |
| Agr2 | Yes | Yes | ER protein, proposed extracellular function in the mucus | (11, 89, 131) |
| ZG16 | Yes | ? | Binds to Gram+ve bacteria | (12, 96) |
| Lypd8 | No | Yes | Binds to Gram−ve bacteria | (85) |
?, unknown secretion from this cell type.