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. 2017 Dec 28;314(3):G418–G430. doi: 10.1152/ajpgi.00183.2017

Fig. 6.

Fig. 6.

CD8+ T cell cytotoxicity and IL-6 levels in PCLS cocultures. CD8+ T cells were isolated from mice immunized with control or ethanol PCLSA and incubated on liver slices from chow-, pair-, or ethanol-fed mice. Samples were collected and tested for percent cytotoxicity and IL-6 levels. A: cytotoxicity generated against liver slices from chow-, pair-, and ethanol-fed mice initiated by CD8+ T cells from mice immunized with control or ethanol PCLSA. #Significantly increased in all 3 groups compared with CD8+ T cells from control PCLSA-injected mice (P < 0.001). *Significantly decreased compared with liver slices from chow-fed liver slices (P < 0.01). B: IL-6 generated in liver slice cultures from chow-, pair-, and ethanol-fed mice cocultured with CD8+ T cells from mice immunized with control or ethanol PCLSA. *Significantly increased compared with chow- or ethanol-fed liver slices. $Significantly increased compared with chow- or pair-fed liver slices incubated with CD8+ T cells from ethanol PCLSA-injected mice (P < 0.001). Values are means ± SE (n = 4 animals per group).