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. 2017 Nov 30;314(3):G431–G447. doi: 10.1152/ajpgi.00281.2017

Fig. 6.

Fig. 6.

Effect of chronic alcohol consumption and hepatocyte-specific Bmal1 gene deletion on glucose metabolism genes. Diurnal gene expression profiles of glucokinase (Gck; A and E), pyruvate kinase, liver (Pklr; B and F), glucose transporter type 1 (Slc2a1/Glut1; C and G), and glucose transporter type 2, liver (Slc2a2/Glut2; D and H) were determined in livers collected from control and alcohol-fed hepatocyte-specific BMAL1 knockout (HBK; E–H) and control genotype (Con; A–D) mice at ZT 3, 7, 11, 15, 19, and 23 h (ZT 0: lights on; ZT 12: lights off, gray shading). mRNA levels were normalized to Gapdh and displayed as a fold-change from the trough of Con mice fed the control diet. Data were fitted to a cosine function and are expressed as means ± SE for n = 5–8 mice/genotype/diet/time point. Solid lines indicate a significant cosine curve fit, whereas dashed lines indicate a nonsignificant fit. Results for Cosinor and ANOVA analyses are provided in Tables 5 and 6, respectively.