Fig. 1.

(CSF1-Fc) does not promote weight gain in neonatal rats. A: rats were injected with PBS or dexamethasone (DEX) on days 14–21 of pregnancy. Control dams were not injected. Box and whisker plots of birth weight; n = 37–65. Results were analyzed with a Mann-Whitney test. ****P < 0.0001. B: bone marrow (BM) from male rats was cultured in 100 ng/ml recombinant human CSF1 (rhCSF1), porcine CSF1-Fc, or without growth factor (cells only) for 7 days. MTT was used to assess cell viability; n = 2 repeat experiments. Graphs show means +SE. C: offspring were injected with PBS or 1 µg/g CSF1 on days 0–5 and weighed daily. Box and whisker plots of weight at day 6; n = 7–19. Results were analyzed by repeated-measures two-way ANOVA (days 0–6).