Table 1.

Body weight and heart and aorta weight relative to body weight, urinary albumin, thromboxane B₂, 8-isoprostane F_2α, malondialdehyde, and nitrate/nitrite: effects of ANG II infusion for 12–14 days and oral tBHQ in C57BL/6 mice

	Vehicle		tBHQ		Effects via ANOVA
Parameter	Sham	ANG II	Sham	ANG II	ANG II	tBHQ	Interaction
Body weight, g	27.7 ± 0.9	27.7 ± 0.5	26.0 ± 0.8	28.4 ± 0.4	NS	NS	NS
Heart/body weight, mg/g	5.4 ± 0.3	4.7 ± 0.2	5.1 ± 0.3	4.8 ± 0.2	NS	NS	NS
Aorta/heart, %	33 ± 2	30 ± 2	32 ± 1	33 ± 3	NS	NS	NS
Urinary albumin, µg/mg creatinine	24.7 ± 2.4	26.1 ± 5.7	33.6 ± 3.3	51.6 ± 7.9†	NS	P < 0.05	NS
Urinary TxB2, ng/mg creatinine	2.06 ± 0.16	2.76 ± 0.19*	1.96 ± 0.06	2.13 ± 0.14†	P < 0.05	NS	P < 0.05
Urinary 8-Iso F2α, ng/mg creatinine	1.41 ± 0.14	1.89 ± 0.15*	1.39 ± 0.07	1.43 ± 0.09†	P < 0.05	NS	P < 0.05
Urinary MDA, mmol/mg creatinine	49.5 ± 5.1	82.5 ± 11.6*	55.4 ± 8.0	53.7 ± 3.9†	P < 0.05	NS	P < 0.05
Urinary NOx, nmol/mg creatinine	246 ± 18	140 ± 11*	226 ± 18	214 ± 24†	P < 0.05	NS	P < 0.05

Values are expressed as means ± SE values (n = 6 per group) for results obtained at days 12–14 of infusion of ANG II or vehicle. MDA, malondialdehyde; tBHQ, tert- butylhydroquinone; NOx, nitrite/nitrate; NS, not significant.

^*P < 0.05, compared with sham.

^†P < 0.05, compared with vehicle.