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. 2017 Nov 22;314(3):R433–R446. doi: 10.1152/ajpregu.00154.2017

Fig. 1.

Fig. 1.

Pulmonary arterial contraction to BAY K8644 (BAYK) and FPL 64176 (FPL) are kinetically distinct. A and B: average isometric contractility response of pulmonary arterial rings exposed to 1 µM BAYK (open circles) and 1 µM FPL (closed squares) isolated from adult and fetal sheep under normoxic conditions. C–F: representative time series traces of the force developed for FPL in the presence of nifedipine (NIF; black) or vehicle (DMSO; gray) for pulmonary arteries from adult (C and D) and fetus (E and F). Values are means ± SE. Data were analyzed with a two-way ANOVA and Bonferroni posttest analysis. **P < 0.01, ***P < 0.001 between BAYK and FPL values at the same time point. FPL responses were obtained in 8/5 adult normoxic (AN) and 5/5 fetal normoxic (FN) arteries and animals, respectively. BAYK responses were from 12/4 AN and 5/5 FN arteries and animals, respectively.