Fig. 4.
Quantitative analysis by real-time PCR showing effects of intravenous (IV) injection of interleukin (IL)-1β or 0.9% saline on mRNA expression of angiotensin-converting enzyme (ACE), angiotensin II type 1a receptor (AT1aR), cyclooxygenase (COX)-2, COX-1, tumor necrosis factor (TNF)-α, IL-1β, TNF-α receptor 1 (TNFR1), and IL-1 receptor (IL-1R) in the hypothalamic paraventricular nucleus (PVN) of rats with a subfornical organ (SFO) lesion (SFO-x) or a sham SFO lesion (SFO-s). Values are means ± SE (n = 6 for each group) and expressed as fold change relative to Veh control. *P < 0.05 vs. SFO-s + IV saline; †P < 0.05 vs. SFO-s + IV IL-1β.