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. 2017 Dec 20;314(3):R478–R488. doi: 10.1152/ajpregu.00287.2017

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Fig. 1. — Genotype confirmation using PCR and immunofluorescence analysis. A: protein tyrosine phosphatase 1B (PTP1B; +/+), heterozygotes (+/−), and proopiomelanocortin (POMC)-Cre positive mice. Positive (+) and negative (−) DNA samples. B: tomato reporter gene expression in POMC-Cre positive neurons of a homozygous PTP1B^flox/flox/POMC-Cre mouse in arcuate nucleus (ARC) and nucleus tractus solitarius (NTS). C: immunohistochemistry of p-STAT3 signaling in the ARC of a PTP1B^flox/flox and PTP1B^flox/flox/POMC-Cre mouse injected intraperitoneally with leptin.