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. 2017 Dec 1;314(3):H669–H680. doi: 10.1152/ajpheart.00431.2017

Table 1.

Systemic characteristics and cardiac function in experimental groups at 16 wk

Parameter Lean MetS MetS + ELAM
Body weight, kg 70.0 ± 10.9 92.0 ± 3.8* 91.7 ± 3.4*
Mean blood pressure, mmHg 99.6 ± 9.7 122.8 ± 11.2* 119.3 ± 2.2*
Total cholesterol, mg/dl 82.5 (76.0–90.5) 414.0 (331.0–506.8)* 383.5 (306.8–410.3)*
HDL-cholesterol, mg/dl 47.7 ± 5.9 134.1 ± 29.7* 124.8 ± 37.7*
LDL-cholesterol, mg/dl 33.8 (26.4–40.3) 369.7 (213.4–489.6)* 286.4 (262.6–468.1)*
Triglycerides, mg/dl 7.8 ± 2.1 18.8 ± 3.4* 21.2 ± 6.9*
Fasting glucose, mg/dl 101.0 ± 2.7 103.7 ± 16.1 107.2 ± 12.5
Fasting insulin, µU/ml 0.4 (0.3–0.5) 0.7 (0.7–0.8)* 0.7 (0.7–0.8)*
HOMA-IR score 0.6 (0.6–0.7) 1.9 (1.5–1.9)* 1.9 (1.8–2.0)*
Heart rate, beats/min 74.6 ± 5.2 82.7 ± 4.4* 81.0 ± 2.5*
Cardiac output, l/min 5.4 ± 0.8 6.0 ± 1.0 5.7 ± 1.0
Stroke volume, ml 72.3 ± 5.4 71.1 ± 5.4 73.8 ± 5.7
Ejection fraction, % 58.8 ± 6.7 53.5 ± 5.4 54.4 ± 2.3
Left ventricular muscle mass, g 140.0 ± 23.9 146.5 ± 27.1 145.7 ± 24.6
Systemic vascular resistance, mmHg⋅min⋅ml−1 1,443.7 ± 206.0 1,670.1 ± 343.5 1,708.5 ± 285.7
Myocardial perfusion, ml·min−1·g−1 1.08 ± 0.15 0.85 ± 0.10* 0.82 ± 0.20*

Values are means or medians (interquartile ranges); n = 6 pigs/group. MetS, metabolic syndrome; ELAM, elamipretide; HOMA-IR, homeostasis model assessment of insulin resistance.

*

P < 0.05 vs. the lean group.

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