Fig. 1.

Effects of graded salt intake and systemic ANG II on heart rate (HR) and mean arterial pressure (MAP). Summary data of HR and MAP over 5 days of baseline and 14 days of subcutaneous infusion of ANG II or vehicle (Veh; normal saline) are shown. Baseline MAP and HR were similar across groups that consumed a normal salt (0.4% NaCl) diet (NSD) and a high-salt (2% NaCl) diet (HSD). Within ~2 days of ANG II infusion (150 ng·kg⁻¹·min⁻¹ sc), MAP increased significantly and remained stably elevated thereafter. ANG II infusion reduced HR similarly in all groups, but the effects were not statistically significant. *P < 0.05 vs. baseline and vs. Veh-NSD and Veh-HSD groups.