Table 4.

Primary parameters of the model

Subject	VD,tot /liters	${\sigma }_{{\text{V}}_{\text{D}}^{\text{*}}}$	VA,tot /liters	${\sigma }_{\ln {\text{C}}_{\text{L}}^{\text{*}}}$	${\sigma }_{\ln {\text{C}}_{\text{d}}^{\text{*}}}$	$\Delta {\text{SpO}}_2$ /%	MSE /10−6
Young #1	0.157 ± 0.007	0.44 ± 0.01	2.39 ± 0.05	0.32 ± 0.02	0.45 ± 0.21	0.6 ± 1.0	1.13
Young #2	0.154 ± 0.008	0.50 ± 0.06	2.73 ± 0.10	0.40 ± 0.01	0.62 ± 0.25	−0.1 ± 0.5	2.75
Young #3	0.166 ± 0.006	0.37 ± 0.03	3.25 ± 0.22	0.43 ± 0.03	0.87 ± 0.13	0.9 ± 1.4	1.84
Young #4	0.176 ± 0.014	0.43 ± 0.01	3.18 ± 0.12	0.35 ± 0.02	0.54 ± 0.29	−1.1 ± 0.7	3.39
Young #5	0.199 ± 0.009	0.38 ± 0.03	4.37 ± 0.25	0.35 ± 0.04	0.53 ± 0.17	0.3 ± 0.9	2.30
Young #6	0.224 ± 0.012	0.34 ± 0.03	4.49 ± 0.11	0.41 ± 0.03	0.70 ± 0.11	0.2 ± 0.6	3.16
Mean	0.179	0.41	3.40	0.38	0.62	–0.1	2.43
CoV	5%	7%	4%	7%	34%
Old #1	0.198 ± 0.009	0.30 ± 0.03	2.88 ± 0.10	0.56 ± 0.05	0.92 ± 0.13	−0.6 ± 0.8	1.43
Old #2	0.192 ± 0.007	0.39 ± 0.05	2.96 ± 0.20	0.38 ± 0.03	0.65 ± 0.17	−0.4 ± 0.5	1.75
Old #3	0.288 ± 0.023	0.25 ± 0.07	3.48 ± 0.12	0.63 ± 0.04	1.04 ± 0.12	−1.9 ± 0.5	4.29
Old #4	0.224 ± 0.010	0.44 ± 0.04	3.83 ± 0.08	0.40 ± 0.02	0.78 ± 0.12	−1.0 ± 0.9	2.24
Old #5	0.309 ± 0.012	0.20 ± 0.05	4.98 ± 0.29	0.56 ± 0.05	1.01 ± 0.09	−1.4 ± 0.4	3.38
Old #6	0.360 ± 0.019	0.33 ± 0.03	6.34 ± 0.17	0.57 ± 0.02	1.01 ± 0.07	−0.2 ± 0.2	5.81
Mean	0.262	0.32	4.08	0.52	0.90	–0.9	3.33
CoV	5%	16%	4%	7%	14%
COPD #1	0.246 ± 0.019	0.42 ± 0.12	2.35 ± 0.23	0.86 ± 0.14	0.87 ± 0.22	−1.0 ± 1.1	7.07
COPD #2	0.394 ± 0.030	0.42 ± 0.16	2.60 ± 0.11	0.83 ± 0.05	1.19 ± 0.39	−1.5 ± 1.2	8.30
COPD #3	0.226 ± 0.015	0.47 ± 0.02	2.66 ± 0.09	0.73 ± 0.04	1.36 ± 0.37	−0.6 ± 0.6	3.59
COPD #4	0.270 ± 0.031	0.55 ± 0.02	3.14 ± 0.20	0.88 ± 0.05	1.50 ± 0.39	−1.0 ± 0.7	7.85
COPD #5	0.344 ± 0.006	0.38 ± 0.01	3.91 ± 0.18	0.71 ± 0.02	1.38 ± 0.07	−2.3 ± 0.8	7.89
COPD #6	0.497 ± 0.083	0.65 ± 0.05	5.38 ± 1.57	0.94 ± 0.13	1.72 ± 0.21	0.0 ± 0.9	13.6
Mean	0.330	0.48	3.34	0.82	1.34	–1.1	8.05
CoV	9%	14%	10%	8%	21%
Analysis of variance
F ratio (BG:WG)	6.0*	5.5*	0.8	43.2***	17.6***	4.8*	26.3***
F ratio (BP:WP)	48.5***	13.2***	42.8***	12.2***	5.2***	4.7***	1.2
ICC	0.99	0.95	0.98	0.99	0.94	0.87

$\Delta {\text{SpO}}_2$ is the difference between pulse oximeter measurements of arterial oxygen saturation during air breathing and calculated pulmonary mixed venous oxygen concentration from the model. MSE is mean squared error. Other parameters are as defined in Table 1. CoV, coefficient of variation; F ratio (BG:WG) is the variance ratio for the between-group to within-group comparison; F ratio (BP:WP) is the variance ratio for the between-participant to within-participant comparison. ICC is the intraclass correlation coefficient. Errors shown are for  ±  1SD.

^*P < 0.05;

^***P < 0.001.