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Schematic representation of interacting partners from early endosome–late endosomal fusion. Rab5C interacts with EEA1 to allow for endosomal maturation and fusion with a late endosome. The late endosome facilitates Rab7A to interact with LBPA, which is involved in PS-ASO escape. Rab5C and EEA1 are returned back to the early endosome by a vesicle, as they remain membrane tethered. LBPA, lysobisphosphatidic acid.
