Table 1.
Type* | Origin of the site being cryptic | No.† |
LC | Loops protruding into the site, making it closed to ligand binding | 21 |
LO | Loops too open in the unbound structure, making the pocket not well-formed | 18 |
S | Side chains protruding into the site in the unbound structure | 18 |
LM | Loops missing in the unbound structure, leading to loss of the pocket | 11 |
I | Interdomain cryptic site, affected by hinge or other motion of the two domains | 11 |
U | Unstructured regions in the unbound structure, in most cases N or C termini | 3 |
SC | Secondary structure elements too close, closing on the pocket | 5 |
SO | Secondary structure elements too far, making the pocket too open | 2 |
SM | Secondary structure elements missing in the unbound or bound structure | 2 |
CT | Very large conformational transition (calmodulin) | 1 |
F | FTMap fails: Pocket is too weak to bind probes | 1 |
Notation used in SI Appendix, Table S1.
Number of cryptic sites of the particular type among the 93 proteins.