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Increased p53 activity in MDMXSG/SG mouse tissues. (A) The thymus of mice 4 h after irradiation was analyzed for apoptosis using TUNEL staining. (B) Quantitation of apoptotic cells in the thymus 4 h after 6 Gy irradiation (n = 3; P < 0.01). Error bars indicate standard deviation. (C) The tissues of mice 4 h after 6 Gy irradiation were analyzed for p53 pathway markers by Western blot. The result is representative of >3 mice for each genotype.
