Table 2.
Crude and Adjusted Associations of RA Status with Elevated Urinary Albumin/Creatinine Ratio
| Crude Model | Extended MV Model | Reduced MV Model | ||||
|---|---|---|---|---|---|---|
| OR | p | OR | p | OR | p | |
| RA | 1.04 | 0.89 | 0.44 | 0.027 | 0.43 | 0.016 |
| Age, per year | 1.04 | 0.031 | 1.04 | 0.017 | ||
| Any college vs. none | 0.44 | 0.006 | 0.47 | 0.008 | ||
| Hormone replacement | 0.50 | 0.13 | 0.49 | 0.091 | ||
| Ever smoking vs. never | 1.04 | 0.88 | ||||
| Reported kidney disease | 0.45 | 0.51 | ||||
| Serum creatinine, per mg/dL | 1.99 | 0.35 | ||||
| log HOMA-IR, per log unit | 1.62 | 0.035 | 1.64 | 0.017 | ||
| Hypertension | 1.85 | 0.056 | 2.13 | 0.009 | ||
| HDL-C, per mg/dL | 1.00 | 0.97 | ||||
| log IL-6, per log unit | 1.56 | 0.012 | 1.57 | 0.008 | ||
| log Homocysteine | 1.07 | 0.90 | ||||
| Any angiotensin receptor blocker use | 1.01 | 0.98 | ||||
| Any diuretic use | 1.38 | 0.38 | ||||
| Any NSAID use | 1.27 | 0.44 | ||||
RA=rheumatoid arthritis; OR=odds ratio; MV=multivariable; HOMA-IR=Homeostatic Model Assessment Insulin Resistance Index; HDL-C=high density lipoprotein cholesterol concentration; IL=interleukin; NSAID=non-steroidal anti-inflammatory drug use